弹性阴性脂质体纳米凝:一种用于局部尼古丁胺胺单核酸输送的新平台
Hongyu Ye1, Yanyan Zhen2, Shuyu Chen3
1Department of Gastroenterology, Wenzhou People's Hospital, The Third Affiliated Hospital of Shanghai University, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, China.
Journal of liposome research
|December 12, 2025
概括
尼古丁胺胺单核酸 (NMN) 对皮肤健康有前途,但在分娩方面遇到困难. 新的弹性阴离子脂肪体纳米凝显著改善NMN.
科学领域:
- 皮肤病学和纳米技术
- 生物材料科学 生物材料科学
- 分子生物学分子生物学
背景情况:
- 尼古丁胺胺 mononucleotide (NMN) 是一个NAD+前体,具有皮肤健康的潜力.
- 局部NMN应用面临着由于皮肤透性和稳定性差的挑战.
- 线粒体氧化应激和ROS生成与皮肤衰老和疾病有关.
研究的目的:
- 开发一种新的输送系统,以增强局部NMN的皮肤透.
- 为改善NMN输送,制造弹性阴阳性脂质体纳米凝 (EC-Lip-纳米凝).
- 评估含有NMN的EC-Lip-nanogels的物理化学特性和皮肤透度的增强.
主要方法:
- 合成Nap-FF-GHK和自组装成阴离子纳米凝.
- 通过结合边缘激活剂,构建弹性阴阳性脂质体 (EC-Lips).
- 将NMN加载到EC-Lip-纳米凝中,并对粒子大小,泽塔潜力和封装效率进行表征.
- 与自由NMN相比,皮肤透增强的评估.
主要成果:
- 装有NMN的EC-Lip纳米凝表现出有利的物理化学特性 (53.2nm大小,+14.0mV泽塔潜力,90.2%的封装效率).
- 与自由NMN相比,EC-Lips和EC-Lip纳米凝显示出显著的透增强 (22.7%和16.0%).
- 开发的纳米凝系统有效地提高了NMN的皮肤透性.
结论:
- EC-Lip-纳米凝是增强局部NMN输送的有希望的平台.
- 这种新型的输送系统可以改善水友生物活性分子的皮肤透性.
- 这些发现表明,在皮肤护理和治疗中,局部NMN应用的转型方法.
相关概念视频
01:22Drug Delivery: Miscellaneous Routes
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs through the...
01:24Modified-Release Drug Delivery Systems: Site-Targeted
Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...