在自闭症谱系障碍中免疫干扰的综合多omics映射
Chun Yan1,2, Fangmei Feng3, Chaoting Lan1
1Liuzhou Hospital of Guangzhou Women and Children's Medical Center, Liuzhou, Guangxi, China.
Clinical and translational medicine
|December 12, 2025
概括
自闭症谱系障碍 (ASD) 涉及免疫系统和代谢变化,影响T细胞,NK细胞和单细胞. 这些免疫变化与ASD症状严重程度相关,建议新的治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 神经发育障碍 神经发育障碍
- 代谢学 代谢学 代谢学
背景情况:
- 自闭症谱系障碍 (ASD) 越来越多地被认可为其系统免疫学的参与.
- 导致ASD的确切免疫机制尚不完全理解.
研究的目的:
- 在ASD中使用集成的多omics全面绘制外围免疫景观.
- 调查免疫/免疫代谢变化与ASD临床严重程度之间的关系.
主要方法:
- 多omics分析包括流细胞测量,单细胞和免疫细胞的大量RNA测序.
- 血蛋白质组和代谢组分析以确定生物标志物.
- 免疫特征与临床严重程度指标的相关性.
主要成果:
- 在ASD中显著的免疫调节失调,与改变的免疫细胞子集和与临床严重程度相关的炎症特征.
- T细胞异常 (频率降低,歪曲的Th1/Th2),自然杀手 (NK) 细胞功能受损,骨髓衍生抑制细胞 (MDSC) 和超炎性单细胞的增加.
- 转录组学揭示了干扰素驱动的信号传递;代谢组学/蛋白组学显示了被破坏的纯素代谢和氧化酸化,与症状严重程度相关.
结论:
- 这些发现支持ASD的系统性免疫代谢框架,同时具有免疫激活和改变的髓状/NK细胞状态.
- 确定了强大的外围免疫和代谢障碍,为生物标志物驱动的分层提供了潜力.
- 失调的免疫子集和血生物标志物突出显示了在ASD中免疫向治疗开发的途径.
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