在中风患者的冷漠的治疗:一个系统的审查
Maria Luisa Ruiz-Franco1, Laura Amaya-Pascasio1, Mercedes Gil-Rodríguez2
1Stroke Unit, Department of Neurology, Torrecárdenas University Hospital, Almería, Spain.
Frontiers in neurology
|December 12, 2025
概括
脑卒中后冷漠的治疗方法,如埃斯基塔洛普拉姆和运动重新学习计划,显示出有前途. 需要进一步的高质量试验来确认它们对中风幸存者的有效性.
科学领域:
- 神经学 神经学
- 精神病学是一个精神病学.
- 康复医学 康复医学 康复医学
背景情况:
- 脑卒中后冷漠是一种常见的神经精神疾病,影响高达三分之一的中风幸存者.
- 它与较差的功能恢复和认知衰退有关.
- apathia 经常被低诊断,需要对有效治疗方法进行审查.
研究的目的:
- 系统地审查目前用于中风后冷漠的药理和非药理治疗方法.
- 评估这些干预措施的有效性和安全性.
主要方法:
- 根据PRISMA指南进行了系统审查.
- 在PubMed,Web of Science和Scopus上进行了相关临床试验的搜索.
- 纳入了10项涉及2359名患者的试验,由两个独立审查员进行数据提取和偏差风险评估.
主要成果:
- 药理学药物如埃斯基塔洛普拉姆和多内佩齐尔显示出潜在的益处.
- 非药物治疗策略包括解决问题的治疗,运动重学计划和策略训练改善了冷漠度得分.
- 高频重复性横磁性刺激 (rTMS) 也显示出有效性,尽管研究异质性得到了注意.
结论:
- 诸如埃斯基塔洛普拉姆,多尼佩西尔,运动重学计划,策略训练和rTMS等干预措施显示出治疗中风后冷漠的潜力.
- 目前的证据有限且异质.
- 更大的,高质量的随机对照试验对于建立最终治疗指南至关重要.
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