在急性缺血性中风中静脉血栓溶解后,基于系统性炎症的血液学指数和90天的功能结果:系统性审查
Huiying Huang1, Weijun Wang1, Qing Ma1
1Department of Neurology, People's Hospital of Leshan, Leshan, Sichuan, China.
Frontiers in neurology
|December 12, 2025
概括
像NLR和SII这样的炎症标志物预测了急性缺血性中风 (AIS) 患者接受IV血栓溶解治疗的不良结果. 早期监测这些血液学指数可以帮助风险分层.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 急性缺血性中风 (AIS) 是全球死亡和残疾的主要原因.
- 用rt-PA进行静脉血栓溶解 (IVT) 是标准的,但结果有很大的差异.
- 系统性炎症越来越被认为是AIS病理生理学和治疗反应的关键因素.
研究的目的:
- 系统地审查在接受IVT的AIS患者中基于炎症的血液学指数作为预后生物标志物的文献.
- 评估各种炎症指数和IVT后的功能结果之间的关联.
主要方法:
- 在PubMed,Embase和Web of Science (2015-2025) 中按照PRISMA指南进行系统的文献搜索.
- 包括成年AIS患者的英语,IVT-only队列研究.
- 使用纽卡斯尔-太华尺度 (NOS) 进行质量评估.
主要成果:
- 包括15项观察性研究,涉及约4000名AIS患者.
- 基线升高或早期的NLR,SII,SIRI和PIV与不良的90天功能结果 (AUC0.70-0.80) 有关.
- 在IVT后24-48小时内,这些指数的动态变化显示出比基线措施更强的预后值.
结论:
- 基于炎症的血液学指数是有价值的,可访问的工具,用于在接受IVT的AIS患者早期风险分层.
- 这些指数可以帮助个性化预后评估.
- 未来的研究应该专注于纵向监测和整合大型队列中的多式联运数据.
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