与糖尿病视网膜病变管理中的传统干预措施相比,抗VEGF治疗的结果
1Department of Ocular Fundus Diseases, Xi'an Bright Eye Hospital, Xi'an, Shaanxi 710068, P.R. China.
Experimental and therapeutic medicine
|December 12, 2025
概括
抗血管内皮生长因子 (anti-VEGF) 疗法在糖尿病视网膜病变 (DR) 的视觉和解剖结果方面通常优于激光光凝. 基于DR阶段和并发症的个性化治疗对于最佳结果至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 医疗治疗 医疗治疗
背景情况:
- 糖尿病视网膜病变 (DR) 是导致视力丧失的主要原因.
- 目前的治疗方法包括抗VEGF疗法,激光光凝和玻璃切除术.
- 需要现实世界的数据来比较治疗疗效,并为临床策略提供信息.
研究的目的:
- 为了观察糖尿病视网膜病变的进展.
- 在现实环境中比较抗VEGF治疗,激光光凝血和玻璃切除术的临床结果.
- 为DR提供最佳治疗策略的信息.
主要方法:
- 展望性,观察性研究.
- 371名DR患者 (466只眼睛) 接受了超过3年的随访.
- 治疗包括抗VEGF,激光,联合疗法或玻璃切除术.
- 评估最佳校正视敏度 (BCVA),中央子场厚度 (CST) 和并发症发生率.
主要成果:
- 与激光相比,抗VEGF治疗显示出明显更大的BCVA改善和CST减少.
- 早期的DR需要较少的抗VEGF注射才能保持稳定.
- 在视力低下的眼睛中,与激光相比,抗VEGF减少了拖拉性视网膜脱落,但增加了持续的斑点.
- 在晚期DR (阶段4-5),抗VEGF和玻璃切除术的视力改善率相似.
结论:
- 抗VEGF疗法在改善DR的视觉和解剖结果方面通常优于激光.
- 治疗策略应根据DR阶段和特定并发症来个性化.
- 抗VEGF治疗是有利于引的预防,而激光可能提供更好的控制复发性胀在某些情况下.
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