相关实验视频

Updated: Jan 8, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

瘤微环境通过铜丰富黑纳米平台进行重编程,用于类死敏感低剂量放射性免疫治疗

Yutong Chen¹, Jin Wang², Daniel Zheng^1,3

¹Department of Oncology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fuzhou, Fujian, 350001, People's Republic of China.

International journal of nanomedicine

|December 12, 2025

概括

一个新的纳米平台 (BPNS@Cu-PEG) 通过诱导细胞死亡和重编程瘤微环境来增强低剂量放射性免疫治疗. 这一策略克服了治疗耐药性,并增强了抗瘤免疫力,并改善了安全性.

科学领域:

纳米医学是一种纳米医学.
癌症免疫疗法癌症免疫疗法
辐射疗法辐射疗法

背景情况:

放射性免疫疗法 (RIT) 的有效性受到免疫抑制性瘤微环境 (TME) 和有限的治疗窗口的阻碍.
克服抗辐射和免疫抑制对于有效的深层和转移性瘤治疗至关重要.

研究的目的:

开发一种新型的纳米平台,通过使瘤对辐射敏感,诱导质亡,并重新编程TME来增强RIT.
为了设计一个PEGylated铜载黑纳米平台 (BPNS@Cu-PEG) 的综合治疗效果.

主要方法:

合成的BPNS@Cu-PEG具有高铜负载 (93%).
评估了辐射敏感和 cuproptosis 诱导的能力.
研究的TME重编程机制:GSH耗尽,ROS放大,缺氧缓解和M2-M1巨细胞再极化.
在体外和体内评估的抗瘤免疫效应.

主要成果:

在体外,BPNS@Cu-PEG有效诱导了cuproptosis和免疫细胞死亡 (ICD).
纳米平台通过消耗GSH,放大ROS,缓解缺氧和再极化巨细胞来重新编程TME.
在体内,BPNS@Cu-PEG抑制了瘤生长,在低剂量放射治疗下刺激了抗瘤免疫力,并证明了有利的安全性.

结论:

建立了一个基于铜的低剂量RIT策略,使用BPNS@Cu-PEG.
该纳米平台有效地抵消放射电阻,并促进全身抗瘤免疫力.
BPNS@Cu-PEG提供了一种强有力的方法来扩大RIT的治疗应用和安全性.

关键词:

黑色是一种黑色.这就是cuproptosis.免疫性细胞死亡免疫性细胞死亡放射性免疫疗法是一种放射性免疫疗法.瘤微环境是一个微环境.

更多相关视频

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Studying Copper Nanoparticle-Induced Programmed Cell Death in Bacteria

Published on: May 16, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...