单细胞转录组学确定了FOSL1-调节的IGFBP3+黑色素瘤亚型作为神经免疫调节信号中心,促进瘤进展
Wenjia Ge1, Ziwei Zhang2, Wenjie Chen3
1Department of Plastic Surgery, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Frontiers in immunology
|December 12, 2025
概括
研究人员确定了一种特定的黑色素瘤细胞亚型 (C2 IGFBP3+),与预后不佳和免疫相互作用有关. 准FOSL1或这种亚型可能会改善黑色素瘤治疗和克服耐药性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
背景情况:
- 黑色素瘤是一种具有高转移率和不良预后的侵袭性皮肤癌.
- 瘤微环境的异质性和耐药性仍然是黑色素瘤治疗的重大挑战.
- 瘤微环境中的神经免疫相互作用至关重要,但尚未完全理解.
研究的目的:
- 为了研究黑色素瘤的细胞异质性.
- 为了识别分子标和促进瘤的黑色素瘤亚型.
- 了解神经免疫相互作用在黑色素瘤进展中的作用.
主要方法:
- 黑色素瘤数据的单细胞RNA测序.
- 细胞类型识别,黑色素瘤细胞亚型和功能基因表达分析.
- 对转录因子网络,细胞间通信和体外功能实验的分析.
主要成果:
- 鉴定出一种独特的黑色素瘤细胞亚型,C2 IGFBP3 +,与晚期瘤阶段相关,并富含免疫调节途径.
- C2亚型通过PROS和MHC-II通路与周围细胞进行通信.
- 确定FOSL1是C2亚型的关键转录因子,促进黑色素瘤细胞迁移,增殖和存活.
结论:
- 免疫调节性C2 IGFBP3+黑色素瘤细胞亚型和转录因子FOSL1在黑色素瘤进展中起着至关重要的作用.
- C2亚型可能充当神经免疫相互作用的中心枢纽,涉及与神经免疫学和疼痛调节相关的途径.
- 准FOSL1或C2亚型通路为开发精密黑色素瘤治疗和克服免疫疗法耐药性提供了潜力.
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