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相关实验视频

Updated: Jan 8, 2026

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年龄,心率变化和fMRI信号变化之间的关联

Jonathan Morris1,2, Stacey M Schaefer1, Yiyi Zhu1,3

  • 1University of Wisconsin-Madison Institute on Aging, Madison, WI, USA.

bioRxiv : the preprint server for biology
|December 12, 2025
PubMed
概括

诸如心率变化 (HRV) 这样的心血管因素会影响大脑的fMRI信号变异 (SD). 较高的HRV与SDBOLD的增加有关,这表明它部分解释了与年龄相关的脑信号变异性下降.

关键词:
衰老的衰老 衰老的衰老大胆信号 信号变化 变化人权高官,人权高人,人权高人.休息状态fMRI的休息状态

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科学领域:

  • 神经成像和心血管生理学
  • 功能磁共振成像 (fMRI) 是一种功能性磁共振成像技术.
  • 心率变化 (HRV) 是指心率的变化.

背景情况:

  • 与年龄相关的fMRI信号变异的随着年龄的减少 (SD) 被广泛报道.
  • 心血管因素,特别是心率变化 (HRV),可能会混这些年龄-SD关联.
  • 以前的研究还没有充分探讨HRV和SD之间的直接关系,特别是在个人中.

研究的目的:

  • 为了研究心率变化 (HRV) 和bold fMRI信号变异 (SD) 之间的关联.
  • 确定HRV是否部分解释了SDBOLD中观察到的与年龄相关的下降.
  • 通过移动窗口分析,检查HRV和SDBOLD之间的内部合.

主要方法:

  • 来自美国两个独立的中年人群 (MIDUS) 样本 (核心和刷新) 的休息状态fMRI数据的分析.
  • 部分最小平方 (PLS) 分析以评估HRV-SDBOLD和年龄-SDBOLD的关联.
  • 一致性和滑动窗口分析,以检查HRV指标 (SDNN,RMSSD,LF,HF) 和SDBOLD之间的个人内关系.

主要成果:

  • 在两个样本中,在HRV和SDBOLD之间发现了显著的积极关联 (变态p<0.018).
  • 全脑年龄-SDBOLD的关联是无意义的,与SDBOLD (约70%的voxels) 广泛的与年龄相关的下降形成对比.
  • 移动窗口分析显示了HRV (SDNN,RMSSD,LF) 和SDBOLD之间的强有力的积极人体内关联,独立于基线水平.

结论:

  • 心率变化 (HRV) 与BOLD fMRI信号变化 (SD) 有积极的关联.
  • 心血管因素,特别是HRV,部分调解了年龄和SD之间的关系.
  • 建议对HRV进行控制,特别是低频组件或SDNN,以隔离SDBOLD分析中的神经效应.