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年龄,心率变化和fMRI信号变化之间的关联

Jonathan Morris^1,2, Stacey M Schaefer¹, Yiyi Zhu^1,3

¹University of Wisconsin-Madison Institute on Aging, Madison, WI, USA.

bioRxiv : the preprint server for biology

|December 12, 2025

概括

诸如心率变化 (HRV) 这样的心血管因素会影响大脑的fMRI信号变异 (SD). 较高的HRV与SD_BOLD的增加有关,这表明它部分解释了与年龄相关的脑信号变异性下降.

科学领域:

神经成像和心血管生理学
功能磁共振成像 (fMRI) 是一种功能性磁共振成像技术.
心率变化 (HRV) 是指心率的变化.

背景情况:

与年龄相关的fMRI信号变异的随着年龄的减少 (SD) 被广泛报道.
心血管因素,特别是心率变化 (HRV),可能会混这些年龄-SD关联.
以前的研究还没有充分探讨HRV和SD之间的直接关系,特别是在个人中.

研究的目的:

为了研究心率变化 (HRV) 和bold fMRI信号变异 (SD) 之间的关联.
确定HRV是否部分解释了SD_BOLD中观察到的与年龄相关的下降.
通过移动窗口分析,检查HRV和SD_BOLD之间的内部合.

主要方法:

来自美国两个独立的中年人群 (MIDUS) 样本 (核心和刷新) 的休息状态fMRI数据的分析.
部分最小平方 (PLS) 分析以评估HRV-SD_BOLD和年龄-SD_BOLD的关联.
一致性和滑动窗口分析,以检查HRV指标 (SDNN,RMSSD,LF,HF) 和SD_BOLD之间的个人内关系.

主要成果:

在两个样本中,在HRV和SD_BOLD之间发现了显著的积极关联 (变态p<0.018).
全脑年龄-SD_BOLD的关联是无意义的,与SD_BOLD (约70%的voxels) 广泛的与年龄相关的下降形成对比.
移动窗口分析显示了HRV (SDNN,RMSSD,LF) 和SD_BOLD之间的强有力的积极人体内关联,独立于基线水平.

结论:

心率变化 (HRV) 与BOLD fMRI信号变化 (SD) 有积极的关联.
心血管因素,特别是HRV,部分调解了年龄和SD之间的关系.
建议对HRV进行控制,特别是低频组件或SDNN,以隔离SD_BOLD分析中的神经效应.

关键词:

衰老的衰老衰老的衰老大胆信号信号变化变化人权高官,人权高人,人权高人.休息状态fMRI的休息状态

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