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蛋白质稳定应激驱动干细胞衰老,克隆性血液形成和白血病

Fanny J Zhou, Michelle K Le, Helen C Wang

    bioRxiv : the preprint server for biology
    |December 12, 2025
    PubMed
    概括

    蛋白质稳定应激驱动血造干细胞衰老和克隆扩张. 热冲击因子1 (Hsf1) 的激活有助于干细胞衰老,但促进了白血病前的生长,将衰老与血液恶性瘤联系起来.

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