梅萨拉与IBS-D:检查其对患者症状和便calprotectin水平的影响:一个随机双盲,安慰剂对照的随机试验
Mohammad Hossein Somi1, Masoud Faghieh Dinavari1, Behnam Sajedi2
1Liver and Gastrointestinal Diseases Research Center, Tabriz University of medical sciences, Tabriz, Iran.
梅萨拉显著改善了生活质量,减少了疼痛,腹部张张和便calprotectin在易怒肠综合征与腹 (IBS-D) 患者. 然而,它并没有显著改变便的形状.
科学领域:
- 胃肠病学 胃肠病学
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 刺激性肠综合征 (IBS) 是一种普遍存在的胃肠疾病.
- 这项研究重点关注具有主要腹 (IBS-D) 和便calprotectin升高的IBS.
- 便中的calprotectin是肠道炎症的标志物.
研究的目的:
- 评估梅萨拉在治疗高便calprotectin的IBS-D患者中的疗效.
- 评估梅萨拉对患者症状和炎症标志物的影响.
主要方法:
- 进行了一项双盲随机临床试验,共90名患者 (年龄在18-45岁).
- 患者被随机分为两个组:梅萨拉辛治疗和安慰剂.
- 这项研究涉及两个组的8周监测期.
主要成果:
- 梅萨拉治疗显著改善了生活质量,减少了疼痛,腹部张张和便中calprotectin水平 (p<0.05).
- 没有观察到对便形式的显著影响 (P=0.11).
- 与安慰剂相比,梅萨拉显著提高了生活质量,降低了排便频率,腹部膨胀和calprotectin水平.
结论:
- 梅萨拉在控制IBS-D患者高便calprotectin的症状和减少炎症方面表现出有效性.
- 治疗对生活质量和关键临床标志物产生积极影响.
- 进一步的研究可能会探索梅萨拉在特定IBS亚型中的作用.
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