在哺乳期的人类母乳中的骨质素
Olivier Prosperi1,2, Beatrice Hanusch1, Sophia Naber1,3
1Research Department of Child Nutrition, University Hospital of Pediatrics and Adolescent Medicine, St. Josef-Hospital, Ruhr University Bochum, Bochum, Germany.
Frontiers in endocrinology
|December 12, 2025
概括
与成熟母乳相比,低碳氧化骨质卡尔辛 (ucOCN) 的胆乳含量是成熟母乳的两倍. 碳氧化骨素 (cOCN) 水平也显示出类似的趋势,但生活方式因素没有影响母乳中的这些与骨相关的蛋白质.
科学领域:
- 人体生理学 人体生理学
- 营养科学 营养科学
- 内分泌学 在内分泌学.
背景情况:
- 母乳的成分动态地适应婴儿的需求,含有与骨相关的蛋白质等生物活性化合物.
- 骨质素 (OCN) 存在于碳氧化 (cOCN) 形式,对骨代谢至关重要,以及低碳氧化 (ucOCN) 形式,可能影响内分泌功能.
- 母乳中cOCN和ucOCN的存在和哺乳期动态以及它们与母亲的生活方式的关系仍在调查中.
研究的目的:
- 为了研究不同哺乳阶段在人母乳中碳化骨素 (cOCN) 和低碳化骨素 (ucOCN) 的存在和度.
- 为了确定母亲的生活方式因素 (饮食,体育活动,BMI,年龄,平价) 是否影响母乳中cOCN和ucOCN的水平.
- 探索母乳中的这些骨相关蛋白质对婴儿和母亲健康的潜在功能作用.
主要方法:
- 收集了98名母亲的母乳样本,分别在分娩后1-3天,7天,14天和3个月的四个时间点.
- 量化总蛋白质,cOCN和ucOCN度,使用双酸试验和酶免疫试验.
- 评估母亲的饮食习惯,身体活动水平,体重指数 (BMI),年龄和以前分娩的数量.
主要成果:
- 相对ucOCN度在乳酪 (0.125 ng/mg蛋白质) 与成熟牛奶 (0.055 ng/mg蛋白质) 相比显著更高.
- 相对cOCN度在整个哺乳期略有下降,较高度往往在初生妇女的乳酪中观察到.
- 包括体力活动,BMI和年龄在内的母亲的生活方式因素与母乳中的ucOCN度没有显著的关联.
结论:
- ucOCN和cOCN都是人类母乳中已确认的成分.
- 度动态表明ucOCN在早期哺乳期 (乳母乳) 中的作用可能更大.
- 需要进一步的研究来阐明ucOCN和cOCN在母乳中的特定功能,无论是婴儿还是母亲.
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