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Updated: Jan 8, 2026

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通过dihapto-coordinated anisole的dearomatization形成异质多环框架的形成

Mason R Ortiz1, Justin T Weatherford-Pratt1, Jeremy M Bloch1

  • 1Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.

Organometallics
|December 12, 2025
PubMed
概括

研究人员开发了一种新的异质取消方法来合成复杂的异质多环框架. 这种新方法有效地产生各种异环化合物,扩大合成化学药物发现的可能性.

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Neutral hydrocarbons like cyclopentadiene with an odd number of carbon atoms and one intervening CH2 group in the ring are not aromatic. Cyclopentadiene with 4 π electrons does not satisfy the 4n + 2 π electron rule. Additionally, the intervening CH2 group is sp3 hybridized and lacks a vacant p orbital, thereby interrupting the overlap of p orbitals in a continuous manner and preventing the delocalization of π electrons throughout the ring.
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