由ocrelizumab诱导的炎症性肠状疾病与和周围干涉:一个病例报告
Caroline Soares1, Ana Canastra2, Ângela Domingues1
1Viseu Dão Lafões Health Unita, Department of Gastroenterology, Viseu, Portugal.
Case reports in gastroenterology
|December 12, 2025
概括
奥克雷利祖马布可以引起免疫媒介性肠球炎,模仿克罗恩病,包括围疾病. 停止使用ocrelizumab可以缓解症状,强调需要对这种不良事件进行临床意识.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 免疫介导性结肠炎 (IMC) 是免疫检查点抑制剂的一种已知的不良事件.
- 其他生物制剂,如抗CD20单克隆抗体,可以引起药物诱导的胃肠道损伤.
- 现在,ocrelizumab的处方信息包括IMC警告,因为已报告的病例.
研究的目的:
- 报告一种新型的ocrelizumab诱导的免疫媒介肠炎病例.
- 为了突出伊莱奥科利和围干扰的潜力,模仿克罗恩病.
- 强调认识到这种不良事件的重要性.
主要方法:
- 一个病人的病例报告经历了经过ocrelizumab治疗后慢性腹.
- 胃肠病变的内镜和组织学评估.
- 在停止使用ocrelizumab后的临床随访.
主要成果:
- 患者患上了免疫媒介性肠球炎,并出现了类似克罗恩病的眼和周表现.
- 内镜和组织学发现无法与炎症性肠病区分开来.
- 停止使用ocrelizumab导致症状和病变完全消失.
- 这一案例代表了首次报告的围干涉的情况.
结论:
- 奥克雷利祖马布可以诱导免疫媒介性肠球炎,其特征模仿克罗恩病.
- 这种情况的管理策略尚未明确定义.
- 提高临床意识和报告这些事件至关重要.
相关概念视频
Inflammatory Bowel Disease II: Crohn's Disease
915
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
915
Inflammatory Bowel Disease I: Ulcerative Colitis
859
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
859
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
459
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
459
Inflammatory Bowel Disease IV: Pharmacological Management
445
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
445
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
708
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
708
Chronic Bowel Disorders: Introduction
732
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
732


