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连接牙周炎和固体瘤的免疫炎症机制:对原始证据的系统审查

Houda El Ayachi¹, Imad Barjij^2,3, Amine Cherkaoui⁴

¹Department of Dental Sciences, Faculty of Medicine, Pharmacy and Dental Medicine, Fez Sidi Mohamed Ben Abdellah University, Fez, MAR.

|December 12, 2025

概括

牙周炎是一种慢性炎症状况,与固体瘤的风险和严重性增加有关. 这一系统性审查突出了共享的炎症途径,包括高细胞因子和微生物转移,将牙疾病与癌症发展联系起来.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
牙周病学牙周病学

背景情况:

牙周炎越来越多地与包括癌症在内的全身性疾病有关.
连接牙周炎和固体瘤的特定免疫炎症途径需要进一步阐明.

研究的目的:

系统地审查有关免疫炎症机制的临床研究,将牙周炎与固体瘤的开始或进展联系起来.

主要方法:

在PubMed,Scopus,Web of Science和Embase中使用PRISMA 2020指南进行系统的文献搜索.
包括19项原始的人类研究,重点关注免疫/炎症生物标志物.
对检查牙周炎和固体瘤关联的研究进行分析.

主要成果:

在牙周炎和结直肠癌,胰腺癌,肺癌,前列腺癌和乳腺癌的风险/严重性增加之间发现了显著的关联.
常见的免疫炎症特征包括IL-6和TNF-α的升高,调节性T细胞的增加和微生物转移 (例如P. gingivalis,F. nucleatum).
在所有研究中,证据质量主要是中等的.

结论:

慢性牙周炎症可能通过系统性炎症,微生物失生症和免疫调节推动癌症发生.
需要进一步的机制和纵向研究来确定因果关系.
将牙周评估整合到医疗保健中可能有助于癌症预防和疾病管理.

关键词:

癌症发生的原因是癌症发生.免疫反应的免疫反应.免疫炎症机制的免疫性炎症机制这是一种炎症炎症炎症炎症.我们的微生物群.牙周炎是指牙周炎的一种疾病.固体瘤是一种固体瘤.系统性健康系统性健康

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