激素治疗的有效性和安全性:叙述性审查
Nello Tommasino1, Maria Carmela Annunziata1, Luca Potestio1
1Section of Dermatology, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy.
Clinical, cosmetic and investigational dermatology
|December 12, 2025
概括
激素疗法,如螺旋和口服避孕药提供有效的,耐受性良好的治疗,特别是对于女性. 这些治疗向激素通路,提供持久的控制和避免抗生素耐药性.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 是一种常见的炎症性皮肤疾病,具有显著的荷尔蒙影响,特别是在女性身上.
- 激素疗法越来越多地用于中度至重度或耐治疗的病例.
研究的目的:
- 审查目前关于激素治疗一般性的疗效和安全性的证据.
- 综合各种激素药物的作用机制,临床结果和安全性资料的数据.
主要方法:
- 关于2010年至2025年间在PubMed,Scopus和Web of Science出版的研究的叙述性综述.
- 包括随机对照试验,队列研究,系统审查和对荷尔蒙疗法的元分析,如COCs,螺旋,酸和clascoterone.
主要成果:
- 螺旋和联合口服避孕药 (COCs) 显著减少了病变,改善了生活质量,具有良好的耐受性.
- 局部抗雄激素clascoterone在最小的系统吸收下显示出有效性;局部spironolactone也显示出有前途.
- 与抗生素相比,激素疗法提供了持久的控制,并减轻了抗菌素耐药性.
结论:
- 激素疗法是治疗的有效和耐受性良好的选择,特别是在女性和耐火性疾病患者中.
- 用荷尔蒙药物准雄激素驱动的途径可以持续改善.
- 个性化治疗应包括这些向激素治疗.
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