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解读心脏发育毒性的表观遗传调节:机制和影响 (综述)

Ziling Qin¹, Ranran Chen², Dianrong Song²

¹Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, P.R. China.

Molecular medicine reports

|December 12, 2025

概括

环境化合物可以通过表观遗传变化损害发育中的心脏. 本综述详细介绍了这些机制,提出了心脏发育毒性的生物标志物,并建议了干预措施.

科学领域:

发展性毒理学发展性毒理学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
心血管胚胎发生.

背景情况:

心脏是脊椎动物发育中的第一个器官,容易受到有毒的侮辱.
外源化合物 (环境化学品,药品) 可以诱导心脏发育毒性.
表观遗传机制是这种毒性的关键媒介.

研究的目的:

综合审查心脏发育毒性的表观遗传调节的分子机制.
分析表观遗传途径的研究进展和技术挑战.
提出表观遗传生物标志物和心脏发育毒性的干预策略.

主要方法:

对表观遗传调节和心脏发育毒性研究的文献综述.
对各种表观遗传机制的分析:DNA甲基化,基因组修饰,非编码RNA,N6-甲基氨酸甲基化和染色质可访问性.
综合当前的研究成果和识别知识差距.

主要成果:

表观遗传修饰显著影响环境化合物如何引起心脏发育毒性.
涉及多种表观遗传途径,提出复杂的研究挑战.
确定了用于监测毒性和潜在治疗点的候选表观遗传生物标志物.

结论:

表观遗传调节在心脏发育毒性中发挥着关键作用.
需要进一步的研究,整合多学科和临床翻译.
开发有针对性的干预措施和生物标志物可以改善心脏发育毒性的预防和管理.

关键词:

通过DNA甲基化.对心脏发育有毒性的毒性染色质可访问性染色质可访问性表观遗传学是指表观遗传学.基质子的修改基质子的修改 m6A甲基化的情况.没有编码的RNAs.

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Epigenetic Regulation

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X-chromosome...

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.