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Autism Spectrum Disorder

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Updated: Jan 7, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

在自闭症谱系障碍和没有自闭症的个体之间,大脑动态功能连接的性别相似之处和差异.

Xue'er Ma¹, Matthew K Belmonte², Yueye Zhao¹

¹Shaanxi Provincial Key Research Center of Child Mental and Behavioral Health, School of Psychology, Shaanxi Normal University, Xi'an, China.

Human brain mapping

|December 12, 2025

概括

自闭症谱系障碍 (ASD) 在男性和女性中显示出共同的和性别特异的脑连接差异. 这些动态连接组变化可能会为自闭症患者提供量身定制的支持.

关键词:

自闭症谱系障碍自闭症谱系障碍大脑连接组连接组动态功能连接的功能连接.性别不一致性性别不一致性性别差异的性别差异.

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Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

相关实验视频

Last Updated: Jan 7, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

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Published on: March 21, 2019

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

科学领域:

神经科学是一个神经科学.
自闭症谱系障碍研究研究
大脑连接学 (Connectomics)

背景情况:

自闭症女性在历史上在神经科学研究中没有得到充分的代表.
有限的研究比较了自闭症男性和女性的神经特征.
了解自闭症大脑功能中的性别差异至关重要.

研究的目的:

调查自闭症谱系障碍 (ASD) 中大脑连接组动态变化的性别相似性和差异.
使用动态功能连接探索性别独立和性别特异的神经特征.
为了将大脑连接组动态与自闭症症状严重程度相关联.

主要方法:

利用滑动窗口方法分析大脑连接体中的动态功能连接.
在节点,边缘和大脑状态水平上检查了模块化,边缘和状态变化.
将98名自闭症患者 (49名女性,49名男性) 与来自ABIDE数据集的98名典型发育 (TD) 对照进行了比较.

主要成果:

自闭症男性和女性都在左中额头回中显示出减少的模块变异性.
在自闭症患者的右嗅觉皮质和右偏中心叶片之间的功能连接中观察到边缘变异性减少.
自闭症患者表现出左桃体和右前带带状肌肉/左右带状肌肉之间边缘变异性的异性转移.
更大的自闭症症状严重程度与高连接性额叶皮层状态的维护减少相关.

结论:

自闭症谱系障碍在动态大脑连接体特征中呈现出共同的和性别差异化的变化.
自闭症连接组动态中的性别特异性模式与性别不一致模型保持一致.
研究结果强调了在理解自闭症神经生物学和制定个性化支持策略方面考虑性别的重要性.