动态醇/二硫化物恒温的比较在皮肤透过的利石切除术和逆行性内手术中
Mehmet Demir1, İsmail Yağmur1, İbrahim Halil Albayrak2
1Department of Urology, Harran University Faculty of Medicine, Sanliurfa.
概括
皮肤透神经切除术 (PNL) 和逆行性内手术 (RIRS) 都会导致类似的全身氧化应激. 动态醇/二硫化物平衡可以监测这种压力,并预测结石手术后的并发症.
科学领域:
- 生物化学 生物化学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 医学科学 医学科学 医学科学
背景情况:
- 当自由基的产生压倒了抗氧化剂防御时,系统性氧化应激会发生.
- 动态醇/二硫化物恒温是氧化应激和氧化还原状态的敏感指标.
- 评估醇/二硫化物恒温参数提供了对手术压力的客观测量.
研究的目的:
- 为了比较皮肤穿神经切除术 (PNL) 和逆行性内手术 (RIRS) 对全身氧化应激的影响.
- 为了评估动态醇/二硫化物恒温作为手术诱导的氧化应激的生物标志物.
主要方法:
- 对80名患有结石的患者进行前性研究,患者接受PNL (n=40) 或RIRS (n=40).
- 在手术前和后测量了总醇,自由醇 (SH) 和二硫化物 (SS) 的血清水平.
- 计算的比率包括SS/总醇,SS/SH和SH/总醇.
主要成果:
- 无论是PNL还是RIRS,都导致整体醇和SH水平在术后显著下降,SS水平和比率显著增加 (p<0.05).
- 这些氧化应激变化的程度在PNL和RIRS组之间没有显著差异 (p>0.05).
- 与无并发症病例相比,患有术后并发症的患者表现出明显较低的硫醇水平 (p<0.05).
结论:
- 无论PNL和RIRS都会诱导相似的全身氧化应激反应,无论其侵入性如何.
- 动态醇/二硫化物恒温参数是监测手术诱导的氧化应激的可靠生物标志物.
- 这些生物标志物可能有助于预测结石手术后的术后并发症.
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