人类中性粒细胞子组的性别特定代谢编程
Anjali S Yennemadi1, Faye K Murphy1, Joseph Keane1
1Department of Clinical Medicine, Trinity Translational Medicine Institute, St James's Hospital, Trinity College Dublin, The University of Dublin, Dublin, Ireland.
Journal of leukocyte biology
|December 12, 2025
概括
男性低密度中性粒细胞 (LDNs) 的新陈代谢比女性LDNs的新陈代谢更高,与正常密度中性粒细胞 (NDNs) 不同. 在LDN中这种特定的代谢差异表明了性别偏差免疫反应的基础.
科学领域:
- 免疫学 免疫学 免疫学
- 代谢过程中的代谢.
- 细胞生物学 细胞生物学
背景情况:
- 已知中性粒细胞代谢的性别差异,但它们对特定中性粒细胞子集的扩展尚不清楚.
- 低密度中性粒细胞 (LDNs) 与疾病和免疫失调有关.
- 正常密度中性粒细胞 (NDN) 是健康个体中大多数中性粒细胞的组成部分.
研究的目的:
- 研究不同中性粒细胞子集 (LDNs和NDNs) 的新陈代谢中的性别差异.
- 要确定在中性粒细胞中观察到的代谢二态化是否延伸到LDN和NDN.
主要方法:
- 从健康的人类捐赠者中分离LDN和NDN.
- 评估细胞代谢,包括氧化酸化和糖解.
- 对成熟度标志物的流细胞计分析 (CD16hi/lo).
主要成果:
- 男性的LDN表现出明显更高的基础氧气消耗率 (OCR) 和ATP产量,而不是女性LDN.
- 在NDN中没有观察到代谢的显著性别差异.
- 与匹配的NDN相比,男性LDN显示出更高的OCR和糖解,而女性LDN的OCR低于他们的NDN.
- 与女性LDN和NDN相比,男性LDN表现出高代谢的表型.
结论:
- 中性粒细胞的LDN表现出特定亚群的性代谢重编程.
- 男性的LDN具有超代谢的表型.
- 这些发现为性别偏差的免疫反应提供了代谢基础,并强调了在针对中性粒细胞的治疗中需要性别分层的方法.
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