门高血压中的血液动力学变化:基于CFD的研究,重点是螺旋流特征
Haonan Li1, Zhenmin Fan1, Na Zhao1
11School of Mechanical Engineering, Jiangsu University of Technology, Changzhou Jiangsu, China.
Acta of bioengineering and biomechanics
|December 12, 2025
概括
门高血压会破坏血液流动的动态,导致螺旋流动受损. 这种螺旋性损失是血栓形成和血管重塑的关键因素,为治疗提供了新的见解.
科学领域:
- 心血管研究的心血管研究.
- 医学成像医学成像
- 流体动力学 流体动力学
背景情况:
- 门高血压 (PHT) 导致严重的并发症,如出血和血栓形成,由于改变了血液流动.
- 了解这些血液动力学变化对于管理PHT至关重要.
研究的目的:
- 为了研究流体结构的变化,切割应力和门高血压中的螺旋性.
- 探索这些血液动力学因素在血栓形成和血管改造中的作用.
主要方法:
- 从CT扫描创建了一个患者特定的门静脉系统模型.
- 利用计算流体动力学 (CFD) 来分析流速,墙面剪切应力 (WSS),振荡剪切指数 (OSI),相对停留时间 (RRT) 和螺旋.
主要成果:
- PHT模型显示流速降低,TAWSS降低,RRT增加,特别是在两叉点附近.
- 在PHT中,螺旋流强度和对称性显著降低,特别是在门静脉分叉处.
- 这些变化与容易发生血栓形成的区域相关.
结论:
- 血液动力学障碍,特别是螺旋性丧失,在PHT并发症中起着重要作用.
- 基于CFD的螺旋性分析为评估PHT中的生物机械风险提供了一种新方法.
- 这些发现可能会指导未来的PHT管理干预策略.
相关概念视频
Bernoulli's Equation for Flow Normal to a Streamline
1.2K
Bernoulli's equation for flow normal to a streamline explains how pressure varies across curved streamlines due to the outward centrifugal forces induced by the fluid's curvature. The pressure is higher on the inner side of the curve, near the center of curvature, and decreases outward to balance these centrifugal forces.
The pressure difference depends on the fluid's velocity and radius of curvature. The pressure variation is minimal in flows with nearly straight streamlines. However, the...
The pressure difference depends on the fluid's velocity and radius of curvature. The pressure variation is minimal in flows with nearly straight streamlines. However, the...
1.2K
Esophageal Varices-II: Clinical Features and Management
340
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
340
Steady, Laminar Flow in Circular Tubes
988
Hagen-Poiseuille flow describes a viscous fluid's steady, incompressible flow through a cylindrical tube with a constant radius R. This flow profile is often applied to understand fluid transport in narrow channels, such as capillaries. It serves as a foundational example of laminar flow. In this model, cylindrical coordinates (r,θ,z) are used to describe the radial (r), angular (θ), and axial (z) dimensions within the tube. For Hagen-Poiseuille flow, the velocity profile is purely axial,...
988
Hepatic Portal System
5.1K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
5.1K
Plane Potential Flows
829
Plane potential flows simplify fluid motion by assuming the fluid to be irrotational and incompressible. These characteristics allow these flows to be described by a velocity potential function, ϕ, representing the flow speed in a given direction, and a stream function, ψ, that visualizes the flow path, both governed by Laplace's equation. These parameters help in estimating flow patterns, velocity distributions, and pressure fields around various hydraulic structures.
Uniform...
Uniform...
829
Esophageal Varices-I: Introduction
1.1K
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
1.1K


