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协同抗菌重矿化:一种生物处理启发的单步纳米粒子诱导液体前体策略,用于功能性牙修复

Luyao Yi¹, Jielong Gao^1,2, Zhengrong Yin³

¹State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China.

|December 12, 2025

概括

这项研究引入了一种仿生方法,使用金纳米颗粒来再生牙和对抗细菌. 纳米粒子诱导液体前体 (NILP) 系统恢复牙结构,并提供对口腔生物膜的双重抗菌作用.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
牙科再生医学牙科再生医学

背景情况:

细菌入侵损害了牙的自然修复,推动了的进展.
开发用于同时修复牙和控制口腔生物膜的策略是具有挑战性的.

研究的目的:

提出一个单步生物模拟方法,用于协同的牙再生和抗菌疗法.
为了利用carboxyl功能化黄金纳米粒子 (AuNPs-COOH) 作为非原蛋白类型.
为了创建一个纳米粒子诱导的液体前体 (NILP) 增强牙修复和虫预防.

主要方法:

AuNPs-COOH被用于稳定无形酸前体,诱导牙重矿化的纤维内矿化.
评估了重新矿化牙的机械性能 (弹性模量和硬度).
通过近红外 (NIR) 光激活了双重抗菌功能 (光热和光动力).
在体外和体外评估了对Streptococcus mutans生物膜的抗菌疗效.
在动物模型中评估了与牙髓干细胞的生物相容性和全身毒性.

主要成果:

通过AuNPs-COOH介导的NILP系统恢复了牙的层次结构和机械特性,与声音牙紧密相匹配.
重矿化牙表现出双重NIR激活的抗菌功能,显著抑制Streptococcus mutans生物膜的形成在体外 (10-20%的控制).
观察到强大的体内抗菌疗效,与牙髓干细胞的良好生物相容性,以及最小的全身毒性.

结论:

通过AuNPs-COOH介导的NILP系统为功能牙再生提供了一个有前途的协同战略.
这种方法有效地对抗口腔生物膜,并防止病的进展.
仿生纳米粒子系统代表了牙再生医学和牙损伤预防方面的重大进步.

关键词:

无形酸是一种无形的酸.它是一种抗菌药物,具有抗菌作用.原蛋白矿化原蛋白矿化牙修复牙修复牙修复金纳米颗粒的金子纳米颗粒作为液体前体的前体.

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