COVID-19和疫苗接种对下尿道症状的影响:来自前性队列研究的见解
Julia Duarte de Souza1, Jose de Bessa2, Natássia Cristina Carboni Truzzi1
1Division of Urology, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.
Neurourology and urodynamics
|December 12, 2025
概括
下尿道症状 (LUTS) 在住院的COVID-19患者,特别是女性中很常见,但随着时间的推移而改善. 意想不到的是,接种疫苗,特别是用非活化病毒疫苗接种疫苗,与住院期间较高的LUTS流行率有关.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 下泌尿道症状 (LUTS) 是一个常见的问题,但其在COVID-19住院患者的患病率和病程尚不清楚.
- 在COVID-19的背景下了解LUTS对于患者管理和识别潜在风险因素至关重要.
研究的目的:
- 调查住院COVID-19患者中LUTS的患病率,临床过程和风险因素.
- 检查LUTS与患者的并发症,COVID-19的严重程度和疫苗接种状态之间的关联.
主要方法:
- 一项前性队列研究,涉及168名因COVID-19住院的成年患者 (2021年7月至2022年3月).
- 在住院期间和出院1个月和3个月后使用验证的问卷 (IPSS,ICIQ-OAB,ICIQ-UI SF) 评估LUTS.
- 多变量后勤回归分析了与性别,并发症,疾病严重程度和疫苗接种状况的关联.
主要成果:
- 31.0%的患者在住院期间经历了中度至重度的LUTS,存储症状占主导地位;36.7%的患者有过度活性膀症状 (OAB),34.5%的患者经历了尿失禁 (UI).
- LUTS,OAB和UI在释放后3个月显著下降.
- 没有发现LUTS与并发症或COVID-19严重程度之间的关联. 完全接种疫苗的个体在住院期间患LUTS的几率较高,特别是那些接种了非活化病毒疫苗的人.
结论:
- LUTS在COVID-19的急性阶段普遍存在,特别是在女性中,但通常在3个月内消失.
- 完全接种疫苗,特别是不活化病毒疫苗,在COVID-19住院期间意外地与中度至重度LUTS的可能性增加有关.
- 需要进一步的研究来阐明这种关联的机制和长期影响.
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