巴黎泌尿细胞学报告系统:什么工作,还有什么需要改进?
1Department of Pathology and Laboratory Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Histopathology
|December 12, 2025
概括
巴黎系统 (TPS) 改善了尿细胞学标准化,用于检测高度泌尿腺癌 (HGUC). 虽然TPS 2.0提供了改进,但整合分子诊断和人工智能对于未来膀癌诊断的进步至关重要.
科学领域:
- 尿路病理学 尿路病理学
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 尿细胞学传统上面临着挑战,对低度瘤的敏感性低,观察者间的变异性高.
- 2016年推出的巴黎系统 (TPS) 旨在标准化尿细胞学,重点关注高度泌尿腺癌 (HGUC) 检测.
研究的目的:
- 审查巴黎系统 (TPS) 对尿细胞学诊断准确性,可重现性和临床实用性的影响.
- 确定TPS的局限性以及其第二版 (TPS2.0) 中引入的进步.
主要方法:
- 文献综述评价了尿细胞学中巴黎系统 (TPS) 的研究.
- 对TPS实施前后的诊断准确性,可重复性和临床实用性数据的分析.
- 对TPS 2.0.0中的局限性和提议改进的评估.
主要成果:
- 通过TPS,提高了HGUC检测的标准化和准确性.
- 局限性仍然存在,包括核与细胞质比率,细胞退化和HGUC变异的挑战.
- TPS 2.0提供了精细的标准和视觉辅助来解决一些已识别的问题.
结论:
- 巴黎系统已经显著推进了尿细胞学,特别是对于HGUC.
- 需要进一步改进,重点是整合分子诊断和人工智能,以全面评估膀癌症.
- 持续演变的TPS是改善尿瘤的诊断结果的必要条件.
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