前列腺与治疗相关的变化:过去,现在和未来的治疗方法
Katrina Collins1, Liang Cheng2
1Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Histopathology
|December 12, 2025
概括
病理学家必须了解前列腺癌治疗方法,包括荷尔蒙,辐射和新型废除疗法,如何改变组织组织学. 识别这些变化对于准确诊断和分类前列腺癌样本至关重要.
科学领域:
- 尿路病理学 尿路病理学
- 在瘤学瘤学.
- 医学组织学 医学组织学
背景情况:
- 前列腺癌管理涉及多种不同的疗法,从既定干预措施到新兴模式.
- 诸如抗雄激素剥夺疗法 (ADT) 和辐射疗法 (RT) 等疗法诱导前列腺组织发生显著的组织学变化.
- 越来越多地使用了新的切除技术,但它们的长期组织学效应需要进一步描述.
研究的目的:
- 审查当前和正在研究的前列腺癌疗法.
- 描述这些治疗对前列腺组织的组织学影响.
- 为病理学家提供指导,评估治疗后的前列腺样本.
主要方法:
- 关于前列腺癌治疗方法及其记录的组织学影响的文献综述.
- 分析各种治疗后良性和恶性前列腺组织的形态变化.
- 综合信息用于诊断解释在治疗后的设置.
主要成果:
- 已建立的疗法 (根性前列腺切除术,ADT,RT) 导致记录良好的,广泛的形态变化.
- 新兴的切除技术 (冷疗法,HIFU,PDT,激光) 也会诱导组织学变化,这些变化仍在被描述.
- 治疗引起的变化可以掩盖残留癌症,复杂分级 (例如,格里森评分),并影响分期准确性.
结论:
- 病理学家需要了解前列腺样本中与治疗相关的组织学变化的范围.
- 准确的解释需要将临床史与观察到的形态效应整合起来.
- 了解不断发展的治疗方法对于维持前列腺癌病理学的诊断准确性至关重要.
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