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儿科创伤性脑损伤的全球流行病学:系统审查和元分析

Ronnie E Baticulon¹, Jinno Jenkin Sy², Joseline Haizel-Cobbina^3,4

¹Department of Neurosciences, Division of Neurosurgery, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.

|December 12, 2025

概括

全球儿科创伤性脑损伤 (TBI) 每年影响每10万名儿童中有226.4人,不同国家发生率和结果存在显著差异. 需要进一步的研究,特别是在低收入国家.

科学领域:

全球健康全球健康
儿科神经学儿科神经学
流行病学流行病学

背景情况:

创伤性脑损伤 (TBI) 是全球儿童死亡和残疾的主要原因.
了解儿童TBI的全球发病率和结果对于公共卫生倡议至关重要.

研究的目的:

为了估计儿童TBI的全球发病率.
为了比较不同国家,地区和收入背景的儿科TBI的临床表现和结果.

主要方法:

从2000年起发表的关于儿科TBI的研究的系统综述.
对人口层面数据的元分析,以计算TBI发病率和死亡率.
汇集医院级数据以确定TBI的死亡率,严重程度和原因.

主要成果:

据估计,儿童TBI的全球发病率为每年每10万名儿童中有226.4人.
据估计,每年与TBI相关的死亡率为每10万名儿童中1.9人.
11.0%的儿科TBI病例是严重的,低收入和中等收入国家的发病率和死亡率更高.
在非洲和低收入国家,道路交通伤害是主要的原因,而在其他地方,跌倒更为常见.

结论:

每年,全球约有540万儿童经历TBI.
观察到的TBI发病率差异可能反映出医疗保健系统能力的真实变化或差异.
对于低收入和中低收入国家,就儿科TBI而言,人口层面的数据显著缺乏.

关键词:

流行病学流行病学全球神经外科全球神经外科神经创伤是一种神经创伤.儿科创伤性脑损伤儿童创伤性脑损伤公共卫生公共卫生

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Traumatic Brain Injury l: Introduction

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DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...