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Updated: Jan 8, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

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多米诺微电离性离子循环/分子内迪尔斯-阿尔德反应,用于快速构建多环架

Takashi Okitsu1, Hikaru Saito1, Kiyoshi Tsuge2

  • 1Faculty of Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama 930-0194, Japan.

The Journal of organic chemistry
|December 12, 2025
PubMed
概括

这项研究引入了一种新的多米诺反应序列,用于从简单的芳香化合物中合成复杂的多环分子. 该方法有效地构建复杂的三维结构,具有高度的立体化学控制.

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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Characteristics of the diene
Conformation
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