在肥胖成年人中维生素D缺乏和抑郁症:NHANES 2009-2018年
Yi Zhang1, Lu Yao2, Jingjie Ren3
1School of Medicine, Sias University, No.168 Renmin Road, Xinzheng City, Zhengzhou, 451100, Henan, China. 21963@sias.edu.cn.
Irish journal of medical science
|December 12, 2025
概括
维生素D缺乏与肥胖成年人患抑郁症的可能性更高有关. 这项研究发现,缺乏维生素D水平在抑郁症患者中更为常见,这表明存在潜在的联系.
科学领域:
- 营养科学 营养科学
- 心理健康研究 心理健康研究
- 公共卫生 公共卫生
背景情况:
- 肥胖经常与维生素D缺乏有关.
- 现有的研究表明,维生素D与抑郁症之间存在联系,但肥胖成年人的关系需要进一步澄清.
研究的目的:
- 为了研究血清维生素D水平与肥胖成年人的抑郁症之间的联系.
- 使用来自国家健康和营养检查调查 (NHANES) 2009-2018年的数据进行此分析.
主要方法:
- 从2009-2018年NHANES中对全国代表性样本 (n=4,822) 的肥胖成年人进行横截面分析.
- 使用患者健康问卷 (PHQ-9) 评估抑郁症;维生素D状况由血清25(OH) D水平确定.
- 调查加权的多变量后勤回归分析,调整了许多共同变量.
主要成果:
- 研究样本中的肥胖成年人中抑郁症的患病率为20%.
- 在16%的抑郁症患者中检测到维生素D不足/缺乏,明显高于非抑郁症患者的12% (P=0.002).
- 在调整了混因素后,维生素D不足/缺乏仍然与更高的抑郁症几率显著相关 (aOR=1.41,95% CI 1.06-1.88).
结论:
- 维生素D不足/缺乏与肥胖成年人抑郁症的可能性增加有关.
- 这些发现突出了这种人群中低维生素D状态和抑郁症之间的潜在联系.
- 由于研究的横截面性质,无法确定因果关系.
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