80岁及以上患者的安全性和有效性:回顾性队列研究
Faith E Dunn1, Bayley Clarke2, Annemarie Newark3
1Department of Obstetrics and Gynecology, Medical University of South Carolina, 96 Jonathan Lucas St Suite 639, Charleston, SC, USA. Faithedunn24@gmail.com.
International urogynecology journal
|December 12, 2025
概括
老年妇女 (≥80) 更有可能停止对过度活跃的膀的纳丁毒素A (BTX-A),但不是因为无效. 尿路感染在65岁以上的女性中更为常见,尽管在老年人群中,整体不良事件并不显著增加.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 老年病的医生 老年病的医生
- 药理学 药理学是指药理学的学科.
背景情况:
- 过度活性膀 (OAB) 显著影响老年人,由于副作用和无效性,治疗选择有限.
- 毒素A (BTX-A) 的注射是OAB管理的常见替代方案.
- 在老年女性群体中,BTX-A的疗效和安全性研究有限.
研究的目的:
- 为了比较BTX-A中止率,治疗失败率,尿路感染率和80岁及以上女性与年轻人队伍的保留率.
- 评估BTX-A在老年人群中的安全性和有效性.
主要方法:
- 在2014年1月至2020年12月期间接受OAB办公室BTX-A的妇女的回顾性队列研究.
- 统计分析包括克鲁斯卡尔-瓦利斯,ANOVA,奇平方和费舍尔精确测试来比较年龄组.
主要成果:
- 总共分析了547名女性,分为三个年龄组:<65 (39%),65-79 (46%) 和≥80 (15%).
- 随着年龄的增长,BTX-A的中止率增加了 (54%<65,58%65-79,72%≥80;p=0.01),由于不有效性而导致的中止没有显著差异.
- 尿路感染 (UTI) 的发生率为19% (<65),29% (65-79) 和29% (≥80;p<0.01). 在65-79岁的群体中,保留率最高 (17%).
结论:
- 80岁及以上的女性最有可能停止服用BTX-A,但不是因为缺乏有效性.
- 虽然65岁以上的女性在BTX-A后出现了更高的尿路感染率,但在≥80组中,整体不良事件并没有显著增加.
- 在老年患者中,BTX-A似乎是过度活跃膀的可行治疗选择,在仔细考虑尿路感染风险的情况下.
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