慢性放射治疗相关不良影响的高压氧疗法:临床重点审查
Cas Stefaan Dejonckheere1, Lukas Käsmann2,3, Leonard Christopher Schmeel1,4
1Department of Radiation Oncology, University Hospital Bonn, Bonn, Germany.
CA: a cancer journal for clinicians
|December 12, 2025
概括
高压氧气疗法可以帮助管理放射治疗的长期副作用,如纤维化和化. 本综述审查了指导其在癌症幸存者护理中的使用的证据.
科学领域:
- 在瘤学瘤学.
- 高压医学的高压医学.
- 辐射瘤学 辐射瘤学
背景情况:
- 放射治疗对于癌症治疗至关重要,但会导致影响生活质量的长期副作用.
- 慢性辐射诱导的疾病,如纤维化,化,囊炎和直肠炎,对幸存者来说构成重大挑战.
- 改善长期癌症存活率需要有效管理这些晚期影响.
研究的目的:
- 批判性地评估高压氧气疗法 (HBOT) 在管理辐射诱导的晚期影响方面的证据.
- 确定有关患者选择,治疗方案和HBOT的长期结果的知识差距.
- 为临床医生提供基于证据的框架,将HBOT纳入幸存者护理.
主要方法:
- 随机试验,队列研究和现实世界的数据的系统审查和批判性评估.
- 分析HBOT的机制,包括血管新生促进,纤维细胞激活和在低氧环境中的组织重塑.
- 对实施HBOT的实际考虑和卫生系统影响进行讨论.
主要成果:
- 在减轻辐射诱导的组织损伤和纤维化方面,HBOT显示出作为辅助治疗的潜力.
- 综合证据强调了患者选择,治疗方案和报告的长期结果的变化.
- 知识上的差距需要进一步的研究,以优化HBOT的有效性和整合.
结论:
- 高压氧气疗法是治疗癌症幸存者的辐射相关晚期影响的有希望的选择.
- 需要进一步的研究来完善最佳的治疗策略,并评估长期益处.
- 基于证据的决策对于将HBOT纳入多学科的幸存者护理至关重要.
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