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Updated: Jan 8, 2026

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PARP1和PARylation通过稳定CSB-RNAPII复合体来促进转录合的DNA修复

Mihaela Robu1, Rashmi G Shah1, Diana van den Heuvel2

  • 1CHU de Quebec Laval University Research Centre, Neuroscience Axis, Quebec City (QC), G1V 4G2, Canada.

Nucleic acids research
|December 12, 2025
PubMed
概括

聚ADP-ribose) 聚合酶-1 (PARP1) 对于启动转录合核酸切除修复 (TCR) 是至关重要的. 在停滞的RNA聚合酶II中,PARP1稳定了Cockayne综合征蛋白B (CSB),促进了DNA修复.

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