通过脂肪细胞O-GlcNAc信号传递对棕色脂肪组织血管化的副刺激
Luwen Li1, Liwei Dong1, Yaping Shan1
1Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Cell reports
|December 12, 2025
概括
暴露于寒冷会增加棕色脂肪组织 (BAT) 中的与O相关的β-N-乙糖胺修饰 (O-GlcNAcylation). 这一过程对BAT血管化和功能至关重要,突出显示了一条新的代谢调节途径.
科学领域:
- 代谢调节 代谢调节 代谢调节
- 脂肪组织生物学 脂肪组织生物学
- 血管生物学 血管生物学
背景情况:
- 棕色脂肪组织 (BAT) 血管化对其热生成功能至关重要.
- 调节BAT血管化的分子机制尚未完全理解.
研究的目的:
- 调查O-链接β-N-乙糖胺修饰 (O-GlcNAcylation) 在BAT血管化中的作用.
- 阐明参与O-GlcNAcylation介导的BAT调节的分子途径.
主要方法:
- 研究了冷暴露对BAT中的O-GlcNAcylation的影响.
- 在棕色脂肪细胞中利用了O-GlcNAc转移酶的遗传除.
- 研究了特异性蛋白1和基林/丁样蛋白 (Kcp) 在BAT血管生成中的作用.
- 评估了葡萄糖胺补充剂对BAT血管化和热生成的影响.
主要成果:
- 急性寒冷暴露提高了BAT中的O-GlcNAcylation.
- 在棕色脂肪细胞中O-GlcNAc转移酶切除损害了BAT血管化.
- O-GlcNAcylation增强了特异性蛋白1的活性,增加了Kcp的表达.
- 通过骨形态遗传蛋白信号传递,KCP促进了BAT血管生成.
- 葡萄糖胺补充剂增加了BAT血管化和热生成.
结论:
- 脂肪细胞O-GlcNAc信号传递是BAT血管化的关键调节器.
- 这一途径涉及Sp1,KCP和BMP信号传输.
- 针对O-GlcNAc信号提供了一个潜在的策略,以提高BAT功能和热生成.
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