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Updated: Jan 8, 2026

A Simple Method to Identify Kinases That Regulate Embryonic Stem Cell Pluripotency by High-throughput Inhibitor Screening
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天真多能性的退出包含一个代谢诱导的对端粒恒常的检查点

Roshni A de Souza1, David Barneda1, Donja Karimlou1

  • 1Department of Metabolism, Digestion, and Reproduction, Institute of Reproductive and Developmental Biology, Faculty of Medicine, Imperial College London, London W12 0NN, UK.

Cell reports
|December 12, 2025
PubMed
概括

一个新的端粒长度检查点将代谢变化与早期胚胎发育期间的基因组完整性联系起来. 代谢变化引发端粒缩短,激活ZSCAN4进行保护并确保端粒恒温.

关键词:
3D球形形状的球形体.在ALT路径上.CP:干细胞研究.在 ZSCAN4 中,您可以使用 ZSCAN4 进行测试.细胞状态过渡 细胞状态过渡早期的小鼠发展小鼠的早期发展.胚胎干细胞是一种胚胎干细胞.脂质滴滴滴滴滴滴滴滴滴滴滴滴滴代谢 代谢 代谢 代谢多能性的多能性.端粒是什么意思 端粒是什么意思

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