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Updated: Jan 8, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
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希斯甲基转移酶DOT1L维持细胞状态,并限制CD8T细胞的细胞毒性潜力

Muddassir Malik1, Willem-Jan de Leeuw1, Muhammad Assad Aslam2

  • 1Division of Gene Regulation, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

Science advances
|December 12, 2025
PubMed
概括

从成熟的CD8T细胞中去除表观遗传调节器DOT1L可以提高它们的细胞毒性,并促进与生俱来的类似记忆特征. 这种重新编程可以提高抗瘤反应性,而不会损害细胞活力.

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