饮食中氨酸比率对肉中对脂多糖的局部和全身炎症反应的影响
A G Anderson1, C N Beck1, J M Santamaria1
1Center of Excellence for Poultry Science, University of Arkansas, Division of Agriculture, Fayetteville, AR 72701, USA.
Poultry science
|December 12, 2025
概括
饮食中氨酸 (Arg) 的比例影响肉天生的免疫力. 增加Arg水平调节了异质细胞和淋巴细胞等炎症标志物,影响了对脂多糖 (LPS) 的免疫反应.
科学领域:
- 动物营养和免疫学
- 禽畜科学 禽畜科学 禽畜科学
- 天生的免疫反应调节.
背景情况:
- 氨酸 (Arg) 是的必需氨基酸,对蛋白质合成和免疫功能至关重要.
- 饮食Arg在天生的免疫系统中发挥着重要作用,超出了基本的生长要求.
- 了解Arg对炎症的影响对于优化肉健康和性能至关重要.
研究的目的:
- 调查饮食中可消化的Arg与可消化的lysine (dArg:dLys) 比率对肉天生的免疫力的影响.
- 为了评估在脂聚糖 (LPS) 挑战之后的局部和全身炎症反应.
- 确定Arg对白细胞形状,细胞因子表达和急性阶段蛋白质的影响.
主要方法:
- 280只雄性肉被食不同dArg:dLys比率 (0.77到1.33) 的饮食.
- 通过在生长的羽毛 (GF) 纸中注射皮内脂聚糖 (LPS) 来诱导炎症反应.
- 测量了白细胞数量,细胞因子mRNA表达 (IL-1β,IL-6,IL-8),血氧化 (NO) 和α-1-酸糖蛋白 (AGP).
主要成果:
- 增加dArg:dLys比率线性增加异形细胞和改变异形细胞对淋巴细胞的比率作为对LPS的反应.
- 血AGP显示出二次反应,而NO水平随着较高的Arg比率线性增加.
- GF-囊细胞因子mRNA表达 (IL-1β,IL-6,IL-8) 显示了对饮食Arg.
结论:
- 饮食中的Arg水平显著影响了患有LPS的 brojler的先天免疫反应.
- 生长羽毛 (GF) 模型是评估饮食对 brojler 免疫功能影响的敏感工具.
- 补充氨酸可以调节关键的炎症指标,这表明它在肉免疫健康管理中的作用.
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