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Updated: May 7, 2026

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化学合成T细胞受体和抗原受体受体使高灵敏性T细胞受体-阴性CD8αβ-CD3阳性T细胞从人类诱导的多能干细胞发育

Chaoqi Zhang1, Michael Rassner2, Yohei Kawai1

  • 1Shin Kaneko Laboratory, Department of Cell Growth and Differentiation, Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, Japan.

Cytotherapy
|December 12, 2025
PubMed
概括

合成T细胞受体 (TCR) 和抗原受体 (STAR) 结构使诱导多能干细胞 (iPSC) 衍生的T细胞能够克服癌症免疫治疗中的挑战. 这些STAR-iT细胞表现出增强的瘤细胞杀伤和改善的抗原敏感性.

关键词:
这种T细胞受体是T细胞受体.仿制性抗原受体的仿制性抗原受体细胞毒性T淋巴细胞诱导的多能干细胞干细胞.合成T细胞受体和抗原受体.与瘤相关的抗原.

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