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Updated: May 3, 2026

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声波喷射质谱的应用用于使用流体透析的血蛋白结合测定

Xinxin Wen1, Jie Wang1, Xiaotong Li1

  • 1DMPK Department, WuXi AppTec, Shanghai, China.

Drug metabolism and disposition: the biological fate of chemicals
|December 12, 2025
PubMed
概括

这项研究将流体透析与声弹射质谱相结合,以进行更快的血蛋白结合测试. 这种新方法在药物发现中显著加快了未结合分量的确定速度.

关键词:
声波喷射质谱学质谱学流体透析是一种流体透析.高通量的高通量.它与等离子体蛋白结合.没有绑定的分数.

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Protein-Drug Binding: Determination Methods01:22

Protein-Drug Binding: Determination Methods

Determining protein-drug binding can be achieved through indirect and direct methods, each providing valuable insights into the interaction between proteins and drugs.
Indirect methods involve isolating the bound drug from its free form in biological samples such as blood, serum, or plasma. These techniques aim to measure the percentage of drugs bound to proteins. Equilibrium dialysis is a commonly used method where the free drug concentration at equilibrium is measured by separating the bound...
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