尤拜万通过NRF2/GPX4通路抑制铁亡来改善白风
Pengyu Wang1, Xiaomin Liu2, Yan Song3
1School of Pharmacy, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, China; Department of Pharmaceutical Engineering, Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing, China.
Journal of ethnopharmacology
|December 12, 2025
概括
奎尔赛丁是尤拜万的关键成分,通过抑制铁亡来对抗白风. 它激活NRF2/GPX4通路,为白风治疗提供了一种新的治疗策略.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
- 细胞生物学 细胞生物学
背景情况:
- 在历史上,Tribulus terrestris L. 已被用于治疗白风.
- 优拜万 (Yubai Wan) 是一种含有 Tribulus terrestris L. 和蜂蜜的配方,用于治疗白风.
- 优拜旺治疗白风的活性化合物和机制尚不清楚.
研究的目的:
- 为了识别优拜旺的活性成分.
- 探索尤拜万治疗白风的机制.
- 为了研究铁死在白风中的作用.
主要方法:
- 使用了代谢学,转录学和临床分析.
- 建立了素诱导的B16细胞和白风的试验猪模型.
- 评估了铁亡标志物和NRF2/GPX4通路.
主要成果:
- 奎尔丁被确定为Yubai Wan的活性成分.
- Vitiligo 患者表现出高铁和铁度.
- 奎尔因通过NRF2/GPX4通路减少铁亡,缓解了几内亚猪的白风症状.
结论:
- 奎尔赛丁是优拜旺治疗白风的主要活性成分.
- 奎尔赛丁在白风中具有抗铁亡作用.
- NRF2/GPX4信号通路对于瑞在白风中的治疗作用至关重要.
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