通过硫化捐赠者的向配方推进治疗方法
Mandeep Kaur Marwah1, Lissette Sanchez-Aranguren1, Hala Shokr2
1Aston Medical School, College of Health and Life Sciences, Aston University, Birmingham, United Kingdom; Aston Research Centre for Health in Ageing, Aston University, United Kingdom.
概括
硫化 (H2S) 显示出治疗前景,但其受控的输送具有挑战性. 本综述探讨了用于持续释放和向药物输送的先进H2S供体配方,以改善患者友好的药物管理.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 药物输送系统 药物输送系统
背景情况:
- 硫化 (H2S) 是一种具有重要治疗潜力的关键生理分子.
- H2S捐赠者在诸如认知功能,炎症,生殖和血压调节等领域已经证明了其益处.
研究的目的:
- 对H2S捐赠者的配方和输送系统的进展进行审查.
- 突出持续H2S释放和改善药物向的方法.
主要方法:
- 文献综述侧重于H2S捐赠者的配方策略.
- 对药物输送系统的分析,以增强H2S的治疗应用.
主要成果:
- 目前的H2S施用方法 (吸入,注射) 不适合患者.
- 配方系统为有效的H2S供体输送提供可调节的特性.
- 配方的进步使得持续的H2S释放和有针对性的管理成为可能.
结论:
- 药物输送系统对于克服H2S供体管理中的挑战至关重要.
- 配方的进步是实现H2S捐赠者的全部治疗潜力的关键.
- 改善的输送方法有望带来更为患者友好的治疗策略.
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