怀孕期糖尿病和8岁至9岁的儿童肺功能在一个多元化的美国队列中
Margaret A Adgent1, Tebeb Gebretsadik2, Paul E Moore3
1Department of Health Policy, Vanderbilt University Medical Center, Nashville, Tennessee.
概括
孕期糖尿病 (GDM) 在怀孕期间的暴露可能导致肺功能减弱和儿童喘风险增加. 这项研究强调GDM是后代呼吸系统不良结果的潜在风险因素.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 呼吸系统医学 呼吸系统医学
背景情况:
- 孕期糖尿病 (GDM) 与影响胎儿发育和后代肺功能的系统性变化有关.
- 虽然GDM与儿童喘有关,但对其对肺功能影响的数据有限.
研究的目的:
- 调查GDM与儿童呼吸系统健康之间的关联.
- 具体地检查肺功能,喘息和喘的发展.
主要方法:
- 从出生到8-9岁的母婴二合体的前性队列研究.
- 通过图表审查评估GDM;通过螺旋计测量肺功能 (FEV1,FVC,FEV1/FVC,FEF25-75).
- 喘和喘息通过问卷进行评估;回归分析用于确定关联.
主要成果:
- 暴露于GDM的儿童在1秒内显著降低了强迫呼气体积 (FEV1) 和强迫呼气流量在生命能力的25%至75%之间 (FEF25-75).
- 与未暴露儿童相比,暴露于GDM的儿童患喘的几率更高.
- 在其他肺功能参数,如强迫生命能力 (FVC) 中没有发现显著差异.
结论:
- 孕期糖尿病可能是儿童肺功能下降的危险因素.
- 暴露于GDM与患儿喘的可能性增加有关.
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