低肌肉密度和5倍的坐站测试预测肝移植候选人的结果不好
Maxence Lepour1, Alicia Delorme1, Alexis Goffaux2
1Department of Gastroenterology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Clinics and research in hepatology and gastroenterology
|December 12, 2025
概括
五次坐立测试是肝移植候选人的最佳预测结果. 这种简单的测试有助于识别需要更密切监测的高风险患者.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 移植手术 移植手术
- 老年病的医生 老年病的医生
背景情况:
- 肌肉参数如肌,肉,骨髓炎和虚弱与肝移植候选人的死亡率较高有关.
- 之前的研究没有在同一患者队列中前性地比较这些与肌肉相关的参数.
研究的目的:
- 确定等待肝移植的肝硬化患者患病率和死亡率的最准确的肌肉预测指标.
- 在这个高风险人群中比较各种肌肉相关参数的预测值.
主要方法:
- 一项前性单中心研究从2021年6月到2023年10月招募了成年肝移植候选人.
- 用计算机断层扫描来评估肌肉质量指数,密度和骨髓病变.
- 使用肝脏脆弱指数和6分钟步行测试,以及5次坐立测试来评估脆弱性.
主要成果:
- 在被列为移植的108名肝硬化患者中,31%患有肌,34%患有骨髓炎,20%是脆弱的.
- 一年生存率为82%.
- 骨髓炎是死亡率的最强单变体预测因素;然而,五次坐立测试被证明是疾病死亡率的最佳多变体预测因素.
结论:
- 五次坐到站测试是肝移植候选人的疾病死亡率最强大的预测指标.
- 这种简单可靠的功能测试对于识别肝移植等待名单上的高风险患者非常有价值.
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