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关于通过非侵入性脑刺激调节精神病特征的可能性:系统性审查和元分析

Célia F Camara¹, Carmen S Sergiou², Andrés Molero Chamizo³

¹Department of Psychology, University of Essex, UK; School of Psychological Sciences, Birkbeck, University of London, UK.

Progress in neuro-psychopharmacology & biological psychiatry

|December 12, 2025

概括

非侵入性脑刺激 (NIBS) 显示出改善精神病症中社会情感缺陷的潜力. 然而,目前在健康成年人身上进行的研究限制了直接应用,强调了对精神病患者进行研究的需要.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
神经调节是一种神经调节.

背景情况:

精神病症涉及社会情感缺陷,包括与神经回路失调相关的同情和内受损.
非侵入性脑刺激 (NIBS) 正成为治疗这些神经失调的潜在干预方法.

研究的目的:

对不同NIBS协议 (rTMS,TBS,tDCS) 在调节社会情感过程中的有效性进行元分析.
评估NIBS作为治疗精神病的潜力.

主要方法:

64项假药或主动控制研究 (122个效果) 的元分析,使用重复的跨磁刺激 (rTMS),Teta爆刺激 (TBS) 和跨直流刺激 (tDCS).
根据刺激参数,协议被分类为激发性或抑制性.

主要成果:

刺激性NIBS协议在社会情感结果中显示出小到中等的改善 (Hedges' g ≈ 0.33).
阴极tDCS (抑制性) 产生了适度的减少 (g = -0.43).
超过90%的研究使用了健康样本; 一项针对精神病患者的研究报告了零效应.

结论:

NIBS显示了对调制与精神病相关的社会情感过程的初步概念验证.
实质性的方法变化和精神病患者缺乏直接证据需要进一步研究.
未来的研究必须解决这些差距,以评估NIBS对精神病治疗的可行性.

关键词:

同理心同理心同情心有过错的感觉.这是一个亲社会化的社会.rTMS的使用情况.tDCSCS 是一个很好的方法.

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