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关于先进的糖化终产品检测的全面审查:从传统到先进的方法

Subhrajeet Sahoo¹, Michael Howsam², Frédéric J Tessier²

¹Symbiosis School of Biological Sciences (SSBS), Symbiosis International (Deemed University) (SIU), Lavale, Pune, 412115, Maharashtra, India.

|December 12, 2025

概括

先进的糖化终产品 (AGEs) 通过糖化形成,并导致糖尿病并发症. 本次审查涵盖了AGE的形成,分类和当前的检测方法,强调LC-MS/MS是最可靠的.

科学领域:

生物化学和分子生物学
内分泌学和新陈代谢学
分析化学分析化学

背景情况:

糖化是一种非酶的过程,产生先进的糖化最终产品 (AGEs).
AGEs在糖尿病并发症和其他糖化介导疾病中发挥着重要作用.
准确量化各种AGE对于了解它们的病理作用至关重要.

研究的目的:

总结AGE形成的分子机制.
根据起源,化学性质和细胞定位来分类AGE.
讨论当前AGE量化技术的范围和局限性.

主要方法:

审查关于AGE形成和检测的现有文献.
分析基于光谱,色谱和免疫测试的方法.
对非侵入性检测技术的评估.

主要成果:

已确定LC-MS/MS为AGE量化中最可靠和最具体的方法.
艾丽莎和光谱学为特定应用提供了切实可行的替代方案.
非侵入性技术显示出前景,但面临成本和争议限制.

结论:

了解AGE的形成和检测对于管理糖化介导疾病至关重要.
需要对既有和新兴的检测技术进行进一步的研究.
准确的AGE测量将提高对其在疾病进展中的作用的理解.

关键词:

年龄的 AGEs.生物标志物生物标志物艾丽莎·伊丽莎·伊丽莎光是一种光效应.这是LC-MS/MS.

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