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Updated: May 8, 2026

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CHO水解酶的特定聚酸盐指纹以及对间接测定的含义

Melanie Maier1, Viktor Gross2, Linus Weiss3

  • 1Bioprocess Development Biologicals, Boehringer Ingelheim Pharma GmbH & Co., KG, Biberach an der Riss, Germany; Institute of Functional Interfaces, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Journal of pharmaceutical sciences
|December 12, 2025
PubMed
概括

这项研究引入了一种新方法,用于分析生物制药中宿主细胞水解酶的聚酸盐降解. RP-UPLC-MS揭示了明显的酶指纹,改善了稳定性评估.

关键词:
降解产品 (s) 降解产品 (s)药物产品是一种药物产品.酵素 (((s) 的使用辅助物质 (s) 是一个辅助物质.单克隆抗体 (monoclonal antibody) 是一种单克隆的抗体.蛋白质配方 (s) 蛋白质配方稳定的稳定性 稳定的稳定性表面活性剂是一种表面活性剂.

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