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Microfluidic Device for Recreating a Tumor Microenvironment in Vitro
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工程瘤的空间异质性在体外.

Changchong Chen1, Zixuan Zhao2, Dong Hua Seah1

  • 1Department of Biomedical Engineering, National University of Singapore, 15 Kent Ridge Crescent, 119276, Singapore.

Advanced drug delivery reviews
|December 12, 2025
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概括

瘤微环境的空间异质性影响癌症的演变和治疗耐药性. 新的工程技术现在可以重建这种复杂性,以更好地理解和治疗创新.

关键词:
药物开发 药物开发工程瘤模型的工程模型.空间异质性 空间异质性瘤微环境是一个微环境.

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科学领域:

  • 瘤学和癌症生物学
  • 生物医学工程 生物医学工程
  • 生物技术是生物技术.

背景情况:

  • 空间异质性,包括细胞组成,表型,细胞外矩阵 (ECM) 和梯度的变化,在瘤微环境中至关重要.
  • 这些空间模式影响瘤的进化,免疫反应和治疗抵抗力.
  • 目前的体外模型缺乏复制体内瘤异质性的结构复杂性.

研究的目的:

  • 审查当前对癌症空间异质性的理解.
  • 探索工程技术如何重建瘤空间组织.
  • 引导瘤生物学和治疗创新的未来发展.

主要方法:

  • 对空间转录学和多重成像技术的进步进行审查.
  • 讨论工程技术,如3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印,3D生物打印.
  • 整合患者衍生细胞,可调节的矩阵环境和空间定义的信号.

主要成果:

  • 工程技术使瘤空间组织和微区域异质性的受控重建成为可能.
  • 这些模型允许整合来自患者的细胞和可调节的环境.
  • 结合空间奥米克,这些模型促进了治疗反应的机械探索和评估.

结论:

  • 使用工程方法重建瘤空间异质性对于理解癌症生物学至关重要.
  • 这些先进的模型为评估治疗疗效和克服免疫疗法耐药性提供了新的途径.
  • 未来的创新在于将空间生物学与个性化癌症治疗的工程策略相结合.