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排水鼻腔通道和周围假肢关节感染:传统的阴道液计数可能是误导性的
Kareme D Alder1, Evan M Dugdale1, Douglas R Osmon2
1Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.
The Journal of arthroplasty
|December 12, 2025
概括
患有排水性鼻通道的患者对周围假肢关节感染 (PJI) 的诊断值较低. 这增加了同胞白细胞 (WBC) 和血清C反应蛋白 (CRP) 测试的假阴性率.
科学领域:
- 整形外科手术 整形外科手术
- 传染病 传染病 传染病 是一种传染病.
- 诊断 实验室医学 诊断 实验室医学
背景情况:
- 已确定的血清和突实验室值有助于诊断周围假肢关节感染 (PJI).
- 在患有鼻腔通道的患者中假设较低的值.
- 这项研究旨在评估PJI患者的诊断标志物.
研究的目的:
- 确定鼻通道是否与较低的血清红细胞沉积率 (ESR),血清C反应蛋白 (CRP),突白细胞 (WBC) 计数和突中性粒细胞百分比相关.
- 研究道对PJI诊断准确性的影响.
主要方法:
- 对于PJI (2000-2020年) 的611次初级全关节关节置换术的回顾性审查.
- 包括191名符合2011年MSIS标准的患者,没有最近的抗生素.
- 在有 (n=58) 和没有 (n=133) 鼻腔通道的患者之间比较实验室值和虚假阴性率.
主要成果:
- 在患有鼻腔通道的患者中显著降低了中枢突白细胞计数,无论是早期还是晚期PJI.
- 在道患者中,PJI检测的虚假阴性率较高,用于突性WBC (38% vs 6%) 和血清CRP (48% vs 15%).
结论:
- 鼻通道是PJI的诊断,尽管实验室值可能较低.
- 鼻通道的存在显著增加了通过突WBC和血清CRP检测PJI的错误负率.
- 临床医生在存在鼻道时,不应仅仅基于较低的实验室值来驳回PJI诊断.
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