"在免疫能力强的宿主中呈现为多器官功能障碍综合征的肺炎"
Debasish Biswal1, Arupparna Sengupta2, Mohit Sharma3
1Assistant Professor, Department of Microbiology, National Cancer Institute Jhajjar, All India Institute of Medical Sciences New Delhi, India.
Indian journal of medical microbiology
|December 12, 2025
概括
一个健康的成年人患上了严重的肺囊炎肺炎 (PJP),这是一种肺部感染,导致器官衰竭. 即使在看似具有免疫能力的个体中,早期诊断和治疗也至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 关键护理医学 关键护理医学
背景情况:
- 肺囊炎 (PJP) 肺炎通常影响免疫功能低下的人.
- 严重的PJP可以在看似免疫能力强的宿主中异常表现出来.
- 这一病例呈现了健康成年人中罕见的严重PJP病例.
研究的目的:
- 描述一个明显具有免疫能力的成年人患有严重的Pneumocystis jirovecii肺炎 (PJP) 的病例.
- 为了突出PJP的非典型表现和并发症.
- 强调在这种情况下早期诊断和管理的重要性.
主要方法:
- 用Grocott Gomori甲胺银 (GMS) 染色的支气管-气泡洗液进行显微镜检查,以确定P. jirovecii囊.
- 对P. jiroveciiDNA确认的支气管-气囊洗液的聚合酶连锁反应 (PCR) 测定.
- 临床监测患者的症状,包括发烧,呼吸障碍和器官功能障碍.
主要成果:
- 患者出现了长时间的发烧,疲劳和急性呼吸困扰综合征 (ARDS).
- 观察到严重的并发症,包括急性损伤和血液问题.
- 通过GMS染色和呼吸道样本的PCR测定,诊断得到证实.
结论:
- 在没有明显的免疫损害的情况下,PJP可以在个体中呈现严重.
- PJP的临床谱系比以前认为的要广泛得多.
- 及时诊断和干预对于改善严重PJP的结果至关重要,无论宿主免疫状况如何.
相关概念视频
01:29Pneumonia II: Pathophysiology
2.5K
The pathophysiology of pneumonia involves the following steps:
2.5K
01:30Pneumonia III: Complications and Assessment
756
Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
756
01:30Pneumonia I: Introduction
698
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
698
01:25Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
01:21Acute Respiratory Failure-II
981
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
981
01:30Acute Respiratory Failure-III
728
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
728