库尔库脂质体嵌入的聚乙烯酒精/酸盐水凝,表现出对pH反应的持续药物释放和抗氧化剂-抗菌活性
Yuan Sun1,2, Cuiqin Jian1,2, Yueshi Sha1,2
1China Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, Zhejiang Sci-Tech University, Hangzhou, China.
Chemistry & biodiversity
|December 12, 2025
概括
一种新型的pH响应型水凝,包含黄素脂质体,可增强治疗伤口的药物输送效果. 这种创新材料可以提高溶解度,生物可用性和治疗炎症的治疗效果.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 纳米技术 纳米技术
背景情况:
- 黄素 (CUR) 具有抗炎,抗氧化和抗菌特性,但具有不良的溶解性和生物利用性.
- 克服这些局限性对于黄素的有效治疗应用至关重要.
研究的目的:
- 开发一种新的pH响应色度测量水凝系统,以增强黄素的输送.
- 评估开发的水凝的物理化学特性,药物释放动力学,生物相容性和治疗疗效.
主要方法:
- 在聚乙烯醇/奇托 (PVA/CS) 基质中将黄脂体 (CL) 纳入,形成PVA/CS/CL水凝.
- 描述CL封装效率,颗粒大小,水凝机械强度,保持水分,以及依赖pH的颜色变化.
- 在体外评估药物释放,生物相容性,抗菌活性和抗氧化能力.
主要成果:
- 优化的CL实现了高封装效率 (95.04%) 和均的颗粒大小 (121.51 nm).
- 该PVA/CS/CL水凝显示了响应pH的颜色变化,提高了机械强度和增强了保留水分.
- 该系统表现出对pH响应的黄素释放,优异的生物相容性 (>88%的细胞活力),强大的抗菌活性 (>90%的抑制) 和高的抗氧化能力 (85.64%的DPPH清除).
结论:
- 开发的pH响应的色度测量水凝系统有效地克服了黄素的不良溶解性和生物可用性.
- 这种双重功能系统显示出作为创伤管理和炎症治疗的有前途平台的巨大潜力.
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