在血清阴性类风湿性关节炎的长期结果
Bradly A Kimbrough1, Roslin Jose George1, Cynthia S Crowson1
1Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Arthritis care & research
|December 12, 2025
概括
大约13%的血清阴性类风湿性关节炎 (RA) 患者在10年内经历了诊断变化. 其中四分之一的患者实现了无药缓解,突出显示了血清阴性RA管理的重要长期结果.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 流行病学 流行病学
背景情况:
- 血清阴性类风湿性关节炎 (RA) 带来了诊断挑战和可变的疾病轨迹.
- 了解长期结果,包括诊断演变和缓解潜力,对于患者管理至关重要.
研究的目的:
- 为了确定10年累计发生的诊断切换在血清阴性RA.
- 在这个人群中评估无药物缓解和启动生物或向合成疾病修饰性抗风湿药物 (b/tsDMARDs) 的率.
主要方法:
- 一个成年居民的队列研究在Olmsted县,MN,与事件血清阴性RA进行了从2005-2023.
- 手动图表审查被用来收集关于诊断,治疗和缓解状态的数据.
- 统计分析包括计算10年累积发病率,并根据死亡和诊断变化的竞争风险进行调整.
主要成果:
- 诊断变化的10年累计发生率为12.8%,脊椎关节炎是最常见的替代诊断.
- 无药物缓解的10年累计发病率为26.6%.
- 启动b/tsDMARD的10年累计发生率为19.9%.
结论:
- 大约13%最初被诊断为血清阴性RA的人在十年内经历了诊断的改变.
- 大约26.6%的血清阴性RA患者在10年内实现了无药缓解.
- 这些发现强调了血清阴性RA的动态性质以及缓解或需要先进疗法的可能性.
相关概念视频
Rheumatic Heart Disease I: Introduction
407
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
407
Rheumatic Heart Disease III: Medical Management
264
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
264
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
443
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
443
Guidelines for Writing Outcome
3.6K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.6K
Classification of Illness
8.5K
The meaning of illness is individualized to each person who experiences an alteration in health. In contrast, disease is a medical term indicating a pathological change in the structure and function of the body or mind. It is a condition that has specific symptoms and boundaries.
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
An illness is a response to a disease in which the person's level of functioning is changed compared with a previous level. The general classification of illness includes acute and chronic.
Acute illness is severe...
8.5K
Longitudinal Research
13.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
13.0K


