抗菌剂的使用和耐药性.
Nada Reza1,2, Vineet Dubey1, Michael Sharland3
1Department of Clinical Pharmacology and Therapeutics, University of Liverpool, Liverpool, UK.
BMJ (Clinical research ed.)
|December 12, 2025
概括
抗菌素耐药性 (AMR) 威胁着医疗保健,促使全球采取政治行动. 虽然高收入国家在新技术方面取得了进展,但低收入国家却落后,这凸显了对抗耐药性感染的公平解决方案的需要.
科学领域:
- 全球健康 全球健康
- 传染性疾病 传染性疾病
- 公共卫生政策 公共卫生政策
背景情况:
- 抗菌素耐药性 (AMR) 对医疗保健的安全性和有效性构成重大威胁.
- 对抗药物耐药性的政治关注越来越大,全球承诺减少死亡率和改善抗生素使用情况证明了这一点.
- 2024年联合国大会会议强调了解决AMR的紧迫性.
研究的目的:
- 审查有关抗微生物药物耐药性的最近的政治行动和政策发展.
- 确定新出现的威胁,并评估针对耐药病原体的可用和新型抗生素.
- 分析AMR管理的全球格局,强调高收入国家与低收入和中等收入国家之间的差异.
主要方法:
- 对最近的政治行动和政策优先级的文献综述.
- 评估当前和新兴的抗菌剂.
- 对抗药物耐药性挑战和解决方案的全球分布的分析.
主要成果:
- 全球对抗抗菌药物耐药性的方法仍然不平衡,在诊断,管理和感染控制方面存在显著的差异.
- 高收入国家正在利用人工智能等先进技术来进行抗菌药物抵抗管理.
- 低收入和中等收入国家对这些进展的获取有限,这影响了它们对抗耐药性感染的能力.
结论:
- 尽管政治参与度增加,但公平获得抗菌药物耐药性解决方案仍然是一个关键挑战.
- 通过有针对性的预防和最佳治疗来保持基本抗生素的疗效,对于全球有效的医疗保健至关重要.
- 解决AMR策略的全球不平衡对于减轻未来威胁和确保全球安全的医疗保健提供至关重要.
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